Engineering chimeric autoantibody receptor T cells for targeted B cell depletion in multiple sclerosis model: An in-vitro study
Background: Recent evidence suggests COMPANY PERFORMANCE MEASUREMENT AND REPORTING METHODS that B cells and autoantibodies have a substantial role in the pathogenesis of Multiple sclerosis.T cells could be engineered to express chimeric autoantibody receptors (CAARs), which have an epitope of autoantigens in their extracellular domain acting as bai